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Listar por autor "Barroso Ceballos, Sonia Inés"
Mostrando ítems 1-19 de 19
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Artículo
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Dagg, Rebecca A.; Zonderland, Gijs; Puig Lombardi, Emilia; Rossetti, Giacomo G.; Groelly, Florian J.; Barroso Ceballos, Sonia Inés; Tacconi, Eliana M. C.; Wright, Benjamin; Lockstone, Helen; Aguilera López, Andrés; Halazonetis, Thanos D.; Tarsounas, Madalena (Springer Nature, 2021)BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour ...
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Artículo
BRCA2 promotes DNA-RNA hybrid resolution by DDX5 helicase at DNA breaks to facilitate their repair
Sessa, Gaetana; Gómez González, Belén María; Silva, Sonia; Pérez Calero, Carmen; Beaurepere, Romane; Barroso Ceballos, Sonia Inés; Martineau, Sylvain; Martin, Charlotte A.; Ehlén, Åsa; Martínez, Juan S.; Lombard, Bérangére; Loew, Damarys; Vagner, Stéphan; Aguilera López, Andrés; Carreira, Aura (Wiley-Blackwell, 2021)The BRCA2 tumor suppressor is a DNA double-strand break (DSB) repair factor essential for maintaining genome integrity. ...
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Artículo
Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
Salas Armenteros, Irene; Barroso Ceballos, Sonia Inés; García Rondón, Ana; Pérez Calero, Mónica; Andújar, Eloísa; Luna Varo, Rosa María; Aguilera López, Andrés (Elsevier, 2019)THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome ...
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Capítulo de Libro
Detection of DNA-RNA hybrids in vivo
García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Humana Press Inc., 2018)DNA-RNA hybrids form naturally during essential cellular functions such as transcription and replication. However, they ...
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Artículo
Epigenetic features of human telomeres
Cubiles de la Vega, María Dolores; Barroso Ceballos, Sonia Inés; Vaquero Sedas, María Isabel; Enguix González, Alicia; Aguilera López, Andrés; Vega Palas, Miguel Ángel (Oxford University Press, 2018)Although subtelomeric regions in humans are heterochromatic, the epigenetic nature of human telomeres remains controversial. ...
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Artículo
Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX
Domínguez Sánchez, María Salud; Barroso Ceballos, Sonia Inés; Gómez González, Belén; Luna Varo, Rosa María; Aguilera López, Andrés (Public Library of Science, 2011)THO/TREX connects transcription with genome integrity in yeast, but a role of mammalian THO in these processes is uncertain, ...
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Artículo
Multiple signaling kinases target Mrc1 to prevent genomic instability triggered by transcription-replication conflicts
Duch, Alba; Barroso Ceballos, Sonia Inés; García Rubio, María Luisa; Seisenbacher, Gerhard; Aguilera López, Andrés (Nature Publishing Group:, 2018)Conflicts between replication and transcription machineries represent a major source of genomic instability and cells have ...
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Artículo
MutSβ regulates G4-associated telomeric R-loops to maintain telomere integrity in ALT cancer cells
Sakellariou, Despoina; Bak, Sara Thornby; Isik, Esin; Barroso Ceballos, Sonia Inés; Porro, Antonio; Aguilera López, Andrés; Bartek, Jiri; Janscak, Pavel; Peña Díaz, Javier (Elsevier, 2022)Up to 15% of human cancers maintain their telomeres through a telomerase-independent mechanism, termed “alternative ...
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Artículo
Polycomb RING1A- and RING1B-dependent histone H2A monoubiquitylation at pericentromeric regions promotes S-phase progression
Bravo, M.; Nicolini, F.; Starowicz, K.; Barroso Ceballos, Sonia Inés; Calés, C.; Aguilera López, Andrés; Vidal, M. (Company of Biologists Ltd, 2015)The functions of polycomb products extend beyond their well-known activity as transcriptional regulators to include genome ...
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Artículo
Roles of human POLD1 and POLD3 in genome stability
Tumini, Emanuela; Barroso Ceballos, Sonia Inés; Pérez Calero, Carmen; Aguilera López, Andrés (Nature, 2016)DNA replication is essential for cellular proliferation. If improperly controlled it can constitute a major source of ...
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Artículo
Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle
Gómez González, Belén; Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Aguilera López, Andrés (Taylor & Francis, 2020)A large body of research supports that transcription plays a major role among the many sources of replicative stress ...
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Artículo
The antitumor drugs trabectedin and lurbinectedin induce transcription-dependent replication stress and genome instability
Tumini, Emanuela; Herrera Moyano, Emilia; San Martín Alonso, Marta; Barroso Ceballos, Sonia Inés; Galmarini, Carlos María; Aguilera López, Andrés (American Association for Cancer Research, 2019)R-loops are a major source of replication stress, DNA damage, and genome instability, which are major hallmarks of cancer ...
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Artículo
The DNA damage response acts as a safeguardagainst harmful DNA–RNA hybrids ofdifferent origins
Barroso Ceballos, Sonia Inés; Herrera Moyano, Emilia; Muñoz Sánchez, Sergio; García Rubio, María Luisa; Gómez González, Belén; Aguilera López, Andrés (EMBO Press, 2019-07-24)Despite playing physiological roles in specific situations, DNA–RNA hybrids threat genome integrity. To investigate how ...
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Artículo
The Fanconi Anemia Pathway Protects Genome Integrity from R-loops
García Rubio, María Luisa; Pérez Calero, Carmen; Barroso Ceballos, Sonia Inés; Tumini, Emanuela; Herrera Moyano, Emilia; Aguilera López, Andrés (Public Library of Science, 2015)Co-transcriptional RNA-DNA hybrids (R loops) cause genome instability. To prevent harmful R loop accumulation, cells have ...
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Artículo
The human nucleoporin Tpr protects cells from RNA-mediated replication stress
Kosar, Martin; Giannattasio, Michele; Piccini, Daniele; Maya Mendoza, Apolinar; García Benítez, Francisco; Bartkova, Jirina; Barroso Ceballos, Sonia Inés; Gaillard, Hélène; Martini, Emanuele; Restuccia, Umberto; Ramírez Otero, Miguel Ángel; Garre, Massimiliano; Verga, Eleonora; Andújar Sánchez, Miguel; Maynard, Scott; Hodny, Zdenek; Costanzo, Vincenzo; Kumar, Amit; Bachi, Angela; Aguilera López, Andrés; Bartek, Jiri; Foiani, Marco (Springer Nature, 2021)Although human nucleoporin Tpr is frequently deregulated in cancer, its roles are poorly understood. Here we show that Tpr ...
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Artículo
The SWI/SNF chromatin remodeling complex helps resolve R-loop-mediated transcription–replication conflicts
Bayona Feliu, Aleix; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; Aguilera López, Andrés (Springer Nature, 2021)ATP-dependent chromatin remodelers are commonly mutated in human cancer. Mammalian SWI/SNF complexes comprise three conserved ...
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Artículo
The yeast and human FACT chromatin-reorganizing complexes resolve R-loop-mediated transcription-replication conflicts
Herrera Moyano, Emilia; Mergui, Xenia; García Rubio, María Luisa; Barroso Ceballos, Sonia Inés; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2014)FACT (facilitates chromatin transcription) is a chromatin-reorganizing complex that swaps nucleosomes around the RNA ...
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Artículo
Topoisomerase 1-dependent R-loop deficiency drives accelerated replication and genomic instability
Sarni, Dan; Barroso Ceballos, Sonia Inés; Shtrikman, Alon; Irony-Tur Sinai, Michal; Oren, Yifat S.; Aguilera López, Andrés; Kerem, Batsheva (Elsevier, 2022)DNA replication is a complex process tightly regulated to ensure faithful genome duplication, and its perturbation leads ...
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Artículo
UAP56/DDX39B is a major cotranscriptional RNA–DNA helicase that unwinds harmful R loops genome-wide
Pérez Calero, Carmen; Bayona Feliu, Aleix; Xue, Xiaoyu; Barroso Ceballos, Sonia Inés; Muñoz Sánchez, Sergio; González Basallote, Víctor M.; Sung, Patrick; Aguilera López, Andrés (Cold Spring Harbor Laboratory Press, 2020)Nonscheduled R loops represent a major source of DNA damage and replication stress. Cells have different ways to prevent ...